Heat Therapy Influences Thermoregulation and Behaviour in HFpEF Rats
Skeletal muscle contractions rely on a finely tuned neurovascular response. This meachanism ensures oxygen delivery matches metabolic demand. A key mechanism, functional sympatholysis, or the attenuation of sympathetic vasoconstriction during exercise, supports blood pressure regulation and exercise tolerance. Impairments in this process have been linked to reduced delivery of oxygen to the muscles in persons suffering from heart failure with preserved ejection fraction (HFpEF), a condition marked by severe exercise intolerance and limited treatment options.